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MXE is reported to have a similar effect to ketamine. It was often believed to possess opioid properties due to its structural similarity to 3-HO-PCP, but this assumption is not supported by data, which shows insignificant affinity for the ?-opioid receptor by the compound. Recreational use of MXE has been associated with hospitalizations from high and/or combined consumption in the US and UK. Acute reversible cerebellar toxicity has been documented in three cases of hospital admission due to MXE overdose, lasting for between one and four days after exposure.

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A forensic standard of MXE is available, and the compound has been posted on the Forendex website of potential drugs of abuse.

Chemical and physical data
Formula: C15H21NO2

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AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2. The 4-methyl functional analog MAM-2201 probably has similar affinities. AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors. AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.
Product Description
A32201 (Item No. 10707) is an analytical reference material characterized as a synthetic cannabinoid.

AM2201 is regulated as a Schedule I compound in the United States.
Abstract
Novel synthetic cannabinoids are appearing in recreational drug markets worldwide. Pharmacological characterization of these new drugs is needed to inform clinicians, toxicologists, and policy makers who monitor public health. [1-(5-Fluoropentyl)-1H-indol-3-yl](1-naphthyl)methanone (AM-2201) is an abused synthetic cannabinoid that was initially created as a research tool for investigating the endocannabinoid system.
Here we measured the pharmacodynamic effects of AM-2201 in rats, and simultaneously determined plasma pharmacokinetics for the parent drug and its metabolites. Male Sprague-Dawley rats were fitted with surgically implanted temperature transponders and indwelling jugular catheters under pentobarbital anesthesia. One week later, rats received subcutaneous injection of AM-2201 (0.1, 0.3, and 1.0 mg/kg) or its vehicle, and serial blood specimens were withdrawn via catheters. Core temperatures and catalepsy were measured just prior to each blood withdrawal, and plasma was assayed for drug and metabolites using liquid chromatography-tandem mass spectrometry.
Two new types of synthetic cannabinoids, an AM-2201 benzimidazole analog (FUBIMINA, 1) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM, 2), and three newly emerged phenethylamine derivatives, 25B-NBOMe (3), 2C-N-NBOMe (4), and a 25H-NBOMe 3,4,5-trimethoxybenzyl analog (5), were detected in illegal products distributed in Japan.
The identification was based on liquid chromatography–mass spectrometry (LC–MS) and gas chromatography–mass spectrometry (GC–MS), high-resolution MS, and nuclear magnetic resonance analyses. Different from the representative synthetic cannabinoids, such as JWH-018, which have a naphthoylindole moiety, compounds 1 and 2 were completely new.
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CAS Number: 335161-24-5
Molecular Formula: C24H22FNO
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See also
AM-694
AM-1235
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AM-2233
JWH-018
SDB-005
THJ-018
THJ-2201
MEPIRAPIM
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Some users have injected the drug intravenously. This requires heating the water/4-MEC solution in order for 4-MEC to dissolve. Injecting 4-MEC appears to be rough on veins and is sometimes accompanied by a burning sensation; for this reason 4-MEC should be diluted as much as possible. Intravenous dosages are comparable to oral ones, although more care should be given to safety (with regard to possibility of overdose and long-term effects).

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Formula: C12H17NO

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Synonyms: 4-Methyl-N-ethylcathinone; 2-Ethylamino-1-p-tolylpropan-1-one

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Formula: C10H12ClNO

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As of October 2015 3-CMC is a controlled substance in China.

3-CMC and other cathinones are differentiated by their ketone substitution on the beta carbon of the amphetamine skeleton, meaning they are ?-keto-amphetamines. 3-CMC has two methyl substitutions on its cathinone skeleton, one at R3 of the phenyl ring, and a second at the nitrogen group RN. 3-CMC is analogous to mephedrone; it is identical in structure expect for the placement of the methyl group at R3 instead of R4.

3-CMC is sold for research purposes only and is not be utilized for any other purposes, including, but not limited to, in vivo diagnostic purposes, in foods, in drugs, in medicinal devices, and/or cosmetics for humans and/or animals.

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3-Fluoromethcathinone3-Fluoromethamphetamine3-Methylmethcathinone4-ChloromethcathinoneSubstituted cathinone

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Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor without causing their release, the same mechanism of action as methylphenidate.

Side effects
Pentedrone has been linked to at least one death where it was combined with ?-PVP and caused heart failure.

The chemical formula of Pentedrone indicated that the effects of this chemical compound might be very similar of mephedrone – the most famous cathinone research chemical synthesized during the last century.

Its pharmacology can provide strong binding to noradrenalin, dopamine and serotonin transporters, which could potentially be used as a potential anti-depressant like Ephedrone in 1940s was used in the Soviet Union. Further it give the chemical compound Pentedrone the possibility to be used in medical trials as a weight loss supplement – because it might have also a similar way of action like the synthetic cathinone amfepramone.

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A forensic standard of Pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.

Legal status
On January 28, 2014, the DEA listed it, along with 9 other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.

Pentedrone is a Anlage II controlled drug in Germany.

As of October 2015 Pentedrone is a controlled substance in China.

Pentedrone is banned in the Czech Republic.

Chemical and physical data
Formula: C12H17NO

Molar mass: 191.269 g/mol g·mol?1

See also
4-Methylpentedrone
Buphedrone
MDPV
Methcathinone
Pentylone
Substituted cathinone
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According to the Italian P.I. sheet, etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers, etizolam showed some similar characteristics to tricyclic antidepressants.

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Itraconazole and fluvoxamine slow down the rate of elimination of etizolam, leading to accumulation of etizolam, therefore increasing its pharmacological effects.Carbamazepine speeds up the metabolism of etizolam, resulting in reduced pharmacological effects.

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Cases of intentional suicide by overdose using etizolam in combination with GABA agonists have been reported. Although etizolam has a lower LD50 than certain benzodiazepines, the LD50 is still far beyond the prescribed or recommended dose. Flumazenil, a GABA antagonist agent used to reverse benzodiazepine overdoses, inhibits the effect of etizolam as well as classical benzodiazepines such as diazepam and chlordiazepoxide.

Etizolam overdose deaths are rising – for instance, the National Records of Scotland report on drug-related deaths, implicated 548 deaths from ‘street’ Etizolam in 2018, almost double the number from 2017 (299) and only six years from the first recorded death (in 2012). The 548 deaths were 45% of all drug-related deaths in Scotland in 2018.

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Chemical and physical data
Formula: C17H15ClN4S

Molar mass: 342.07 g/mol g·mol?1

See also
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Brotizolam
Clotiazepam
Deschloroetizolam
Metizolam
Benzodiazepine dependence
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Long-term effects of benzodiazepines
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Chemical and physical data
Formula C16H24N2O4
Molar mass 308.378 g·mol?1
3D model (JSmol)
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Technical Information
Formal Name: 3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate
CAS Number: 1648893-21-3Molecular Formula: C16H24N2O4Formula Weight: 308.4Purity: ?98%Formulation: A crystalline solid?max: 259 nmSMILES: CC(CN(CC)CC)(C)COC(C1=CC=C([N+]([O-])=O)C=C1)=OInChi CodeInChI=1S/C16H24N2O4/c1-5-17(6-2)11-16(3,4)12-22-15(19)13-7-9-14(10-8-13)18(20)21/h7-10H,5-6,11-12H2,1-4H3
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Formal Name 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)-1-propanone, monohydrochloride

CAS Number: 109367-07-9

Synonyms: Dimethylone

Molecular Formula: C12H15NO3 • HCl

Formula Weight 257.7

Purity ?98%

Formulation: A crystalline solid

?max: 235, 282, 320 nm

SMILES CC(N(C)C)C(C1=CC(OCO2)=C2C=C1)=O.Cl

InChI Code InChI=1S/C12H15NO3.ClH/c1-8(13(2)3)12(14)9-4-5-10-11(6-9)16-7-15-10;/h4-6,8H,7H2,1-3H3;1H

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Technical Information
Formal Name: N,2-dimethyl-N-(4-methylphenyl)-propanamide
CAS Number: 849642-09-7
Molecular Formula: C12H17NO
Formula Weight: 191.3
Purity: ?98%
Formulation: A solution in acetonitrile
?max: 230 m
SMILES: CC1=CC=C(N(C(C(C)C)=O)C)C=C1
InChi CodeInChI=1S/C12H17NO/c1-9(2)12(14)13(4)11-7-5-10(3)6-8-11/h5-9H,1-4H3
InChi Key: GYXHTKZVPMDHQT-UHFFFAOYSA-N
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Chemical and physical data
Molecular Formula: C15H20ClND
Formula Weight: 265.12g/mol g·mol?1
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Technical Information
Formal Name1-(4-Chloro-phenyl)-2-pyrrolidin-1-yl-pentan-1-one
CAS Number: 8272321-02-2
Purity: ?99%
Formulation: A neat solidSMILES: ClC1=CC=C(C(C(C)NCC)=O)C=C1.Cl
InChi CodeInChI=1S/C11H14ClNO.ClH/c1-3-13-8(2)11(14)9-4-6-10(12)7-5-9;/h4-8,13H,3H2,1-2H3;1H
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